Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD025 |
| Compound Name | Germacrone |
| Phytochemical category | Monocyclic sesquiterpenoid |
| PubChem Id | 6436348 |
| IUPAC Name | (3E,7E)-3,7-dimethyl-10-propan-2-ylidenecyclodeca-3,7-dien-1-one |
| Molecular Formula | C15H22O |
| Canonical SMILES Notation | CC1=CCC(=C(C)C)C(=O)CC(=CCC1)C |
| Binomial Name | Curcuma zedoaria |
| Vernacular Names | White turmeric/Kichili kizhangu/Kachoram/Amb halad |
| Plant Part | Rhizome |
| Family | Zingiberaceae |
| Description | Pseudorabies virus, Porcine parvovirus, and Influenza virus |
| Mechanism of action | It inhibts by inhibit PRV replication by affecting cell antiviral mechanism. |
| Molecular weight | 218.33 g/mol |
| XLOGP3 | 3.46 |
| Num. H-bond acceptors | 1 |
| Num. H-bond donors | 0 |
| Rotatable bonds | 0 |
| Topological polar surface area | 17.07 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | He W, Zhai X, Su J, Ye R, Zheng Y, Su S. Antiviral activity of germacrone against pseudorabies virus in vitro. Pathogens. 2019 Dec;8(4):258. Chen Y, Dong Y, Jiao Y, Hou L, Shi Y, Gu T, Zhou P, Shi Z, Xu L, Wang C. In vitro antiviral activity of germacrone against porcine parvovirus. Archives of virology. 2015 Jun 1;160(6):1415-20. |
