Indian Plant AntiViral Compound DataBase (IMPAC) is a web-based open source curated database of phytochemical compounds, exclusively focusing on the Indian medicinal plants with antiviral therapeutic effect. As of August 2021, IMPAC Database contains 50 entries covering 31 Indian medicinal plant species and 49 viral different viral infections, each containing 24 descriptive fields ranging from compound structure, nomenclature, source plant of Indian origin, its taxonomic details to druglikeness, a short description of the compound’s antiviral activity and its mechanism of action. This database was created by compiling information from various scientific literature resources on traditional medicinal plants used for treating viral infections in Indian systems of medicine like Siddha, Ayurvedha, and other folk medicinal practices. As the database covers taxonomical, pharmacological, and biochemical aspects of the bioactive compounds from plants of Indian origin, it would be a versatile tool for the researchers worldwide to readily obtain vast information on the antiviral compound of interest needed for their virtual screening, pharmacophore mapping, molecular modeling, and other similar research studies.