Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD040 |
| Compound Name | Pentagalloylglucose |
| Phytochemical category | Polyphenolic tannin |
| PubChem Id | 65238 |
| IUPAC Name | [(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3,4,5-trihydroxybenzoate |
| Molecular Formula | C41H32O26 |
| Canonical SMILES Notation | C1=C(C=C(C(=C1O)O)O)C(=O)OCC2C(C(C(C(O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C(=C5)O)O)O)OC(=O)C6=CC(=C(C(=C6)O)O)O |
| Binomial Name | Terminalia chebula |
| Vernacular Names | Kadukkai/Karakkaya/Harad/Myrobalan |
| Plant Part | Fruit |
| Family | Combretaceae |
| Description | Influenza A virus, Herpes simplex virus type 1, and SARS-CoV-2. |
| Mechanism of action | It inhibits the by interacting with the viral hemagglutinin. PGG did not affect viral protein synthesis or nuclear transport of viral nucleoprotein (NP) but greatly reduced plasma membrane accumulation of NP protein at the late stage of the replication cycle; inhibits viral budding, and blocks the fusion of spike-RBD to ACE-2 receptors. |
| Molecular weight | 940.68 g/mol |
| XLOGP3 | 3.59 |
| Num. H-bond acceptors | 26 |
| Num. H-bond donors | 15 |
| Rotatable bonds | 16 |
| Topological polar surface area | 444.18 Ų |
| Bioavailability Score | 0.17 |
| Druglikeness | No |
| Lipinski | 3 violation |
| References | Liu G, Xiong S, Xiang YF, Guo CW, Ge F, Yang CR, Zhang YJ, Wang YF, Kitazato K. Antiviral activity and possible mechanisms of action of pentagalloylglucose (PGG) against influenza A virus. Archives of virology. 2011 Aug;156(8):1359-69. Sharma R, Prajapati GK, Akhoury G. Pentagalloylglucose, a phytochemical from Terminalia chebula can efficiently prevent SARS-CoV-2 entry: In Silico study. Israel Journal of Plant Sciences. 2021 Mar 18;1(aop):1-9. |
