Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD039 |
| Compound Name | Palmatine |
| Phytochemical category | Berberine alkaloid |
| PubChem Id | 19009 |
| IUPAC Name | 2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium |
| Molecular Formula | C21H22NO4+ |
| Canonical SMILES Notation | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC |
| Binomial Name | Tinospora cordifolia |
| Vernacular Names | Shindilakodi/Tippa teega/Gudichi |
| Plant Part | Leaves |
| Family | Menispermaceae |
| Description | West nile virus, Dengue virus, and Yellow fever virus. |
| Mechanism of action | It inhibits viral proteases. |
| Molecular weight | 480.59 g/mol |
| XLOGP3 | 2.63 |
| Num. H-bond acceptors | 8 |
| Num. H-bond donors | 4 |
| Rotatable bonds | 7 |
| Topological polar surface area | 125.68 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | No |
| Lipinski | 0 violation |
| References | Jia F, Zou G, Fan J, Yuan Z. Identification of palmatine as an inhibitor of West Nile virus. Archives of virology. 2010 Aug;155(8):1325-9. Saraswat J, Singh P, Patel R. A computational approach for the screening of potential antiviral compounds against SARS-CoV-2 protease: Ionic liquid vs herbal and natural compounds. Journal of molecular liquids. 2021 Mar 15;326:115298. |
