Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD034 |
| Compound Name | Methyl allyl thiosulfinate |
| Phytochemical category | Thiosulfinate |
| PubChem Id | 129712276 |
| IUPAC Name | 3-methoxysulfinylsulfanylprop-1-ene |
| Molecular Formula | C4H8O2S2 |
| Canonical SMILES Notation | COS(=O)SCC=C |
| Binomial Name | Allium sativum |
| Vernacular Names | Vellaipoondu/Lasan/Vellulli/garlic |
| Plant Part | Shoot/Bulb |
| Family | Alliaceae |
| Description | Dengue virus, Herpes simplex virus type 1 and 2, Vaccinia virus, Vesicular stomatitis virus, Parainfluenza, and Human rhinovirus type 2. |
| Mechanism of action | It interferes with the glycans on the spike during viral entry, release; inhibits viral adsoprtion and penetration; It is a TNF-? inhibitor, Immunomodulatory and antiinflammatory agent |
| Molecular weight | 152.24 g/mol |
| XLOGP3 | 0.97 |
| Num. H-bond acceptors | 2 |
| Num. H-bond donors | 0 |
| Rotatable bonds | 4 |
| Topological polar surface area | 70.81 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | Shoji S, Furuishi K, Yanase R, Miyazaka T, Kino M. Allyl compounds selectively killed human immunodeficiency virus (type 1)-infected cells. Biochemical and biophysical esearch communications. 1993 Jul 30;194(2):610-21. Hall A, Troupin A, Londono-Renteria B, Colpitts TM. Garlic organosulfur compounds reduce inflammation and oxidative stress during dengue virus infection. Viruses. 2017 Jul;9(7):159. |
