Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD021 |
| Compound Name | Fisetin |
| Phytochemical category | Flavanoid |
| PubChem Id | 5281614 |
| IUPAC Name | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one |
| Molecular Formula | C15H10O6 |
| Canonical SMILES Notation | C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C=C(C=C3)O)O)O)O |
| Binomial Name | Azadirachta indica |
| Vernacular Names | Vepilai/Vepaku/Margosa/Neem |
| Plant Part | Leaf |
| Family | Meliaceae |
| Description | Hematopoietic necrosis virus, Viral hemorrhagic septicemia virus, Feline calicivirus, Murine norovirus, Herpes virus type I,Dengue virus, Chikungunya, and SARS-CoV-2. |
| Mechanism of action | It inhibits the viral replication by binding to the viral RNA, thus impeding polymerase activity; inhibits the non structural activities. |
| Molecular weight | 286.24 g/mol |
| XLOGP3 | 1.97 |
| Num. H-bond acceptors | 6 |
| Num. H-bond donors | 4 |
| Rotatable bonds | 1 |
| Topological polar surface area | 111.13 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | Lyu SY, Rhim JY, Park WB. Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. Archives of pharmacal research. 2005 Nov;28(11):1293-301. Kang SY, Kang JY, Oh MJ. Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro. The journal of Microbiology. 2012 Apr;50(2):293-300. Lalani S, Poh CL. Flavonoids as antiviral agents for Enterovirus A71 (EV-A71). Viruses. 2020 Feb;12(2):184. |
