Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD008 |
| Compound Name | Carvacrol |
| Phytochemical category | Phenolic monoterpenoid |
| PubChem Id | 10364 |
| IUPAC Name | 2-methyl-5-propan-2-ylphenol |
| Molecular Formula | C10H14O |
| Canonical SMILES Notation | CC1=C(C=C(C=C1)C(C)C)O |
| Binomial Name | Cinnamonium verum |
| Vernacular Names | Karuvapattai//Dalchini |
| Plant Part | Tree bark |
| Family | ?Lauraceae |
| Description | Herpes simplex virus, Feline calicivirus, Murine norovirus, Hepatitis A virus, and SARS-CoV-2. |
| Mechanism of action | It inhibits the proliferation process, TNF-? increasing levels, decreasing RIP3 and MLKL protein expressions through the intracellular RIP3-mediated programmed cell necrosis pathway; Also inhibits by reversing the ubiquitination decrease levels; inhbits viral replication process. |
| Molecular weight | 150.22 g/mol |
| XLOGP3 | 3.49 |
| Num. H-bond acceptors | 1 |
| Num. H-bond donors | 1 |
| Rotatable bonds | 1 |
| Topological polar surface area | 20.23 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | Wang L, Wang D, Wu X, Xu R, Li Y. Antiviral mechanism of carvacrol on HSV-2 infectivity through inhibition of RIP3-mediated programmed cell necrosis pathway and ubiquitin-proteasome system in BSC-1 cells. BMC Infectious Diseases. 2020 Dec;20(1):1-6. |
