Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD006 |
| Compound Name | Berberine |
| Phytochemical category | Isoquinoline alkaloid |
| PubChem Id | 2353 |
| IUPAC Name | 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene |
| Molecular Formula | C20H18NO4+ |
| Canonical SMILES Notation | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC |
| Binomial Name | Tinospora cordifolia |
| Vernacular Names | Shindilakodi/Tippa teega/Gudichi |
| Plant Part | Leaf |
| Family | Menispermaceae |
| Description | Human cytomegalovirus, Influenza, Hepatitis C virus, and SARS-CoV-2. |
| Mechanism of action | It impedes HCVcc attachment and entry/fusion steps without inactivating the free virus particles or affecting the expression of host cell entry factors and post-entry viral replication.? |
| Molecular weight | 336.36 g/mol |
| XLOGP3 | 3.62 |
| Num. H-bond acceptors | 4 |
| Num. H-bond donors | 0 |
| Rotatable bonds | 2 |
| Topological polar surface area | 40.80 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | Hung TC, Jassey A, Liu CH, Lin CJ, Lin CC, Wong SH, Wang JY, Yen MH, Lin LT. Berberine inhibits hepatitis C virus entry by targeting the viral E2 glycoprotein. Phytomedicine. 2019 Feb 1;53:62-9. Varghese FS, van Woudenbergh E, Overheul GJ, Eleveld MJ, Kurver L, van Heerbeek N, van Laarhoven A, Miesen P, den Hartog G, de Jonge MI, van Rij RP. Berberine and obatoclax inhibit SARS-CoV-2 replication in primary human nasal epithelial cells in vitro. Viruses. 2021 Feb;13(2):282. |
