Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD002 |
| Compound Name | Allicin |
| Phytochemical category | Organosulfur |
| PubChem Id | 65036 |
| IUPAC Name | 3-prop-2-enylsulfinylsulfanylprop-1-ene |
| Molecular Formula | C6H10OS2 |
| Canonical SMILES Notation | C=CCSS(=O)CC=C |
| Binomial Name | Allium sativum |
| Vernacular Names | Vellaipoondu/Lasan/Vellulli/Garlic |
| Plant Part | shoot/Bulb |
| Family | Alliaceae |
| Description | Parainfluenza virus type 3, Vesicular stomatitis virus, Herpes simplex virus, Non-enveloped viruses like Human rhinovirus type 2 and Vaccinia virus. |
| Mechanism of action | It displays activity against latent and lytic Kaposi sarcoma-associated herpesvirus. Its activity against non-enveloped virus may have been due to inhibition of viral adsorption or penetration |
| Molecular weight | 162.27 g/mol |
| XLOGP3 | 1.31 |
| Num. H-bond acceptors | 1 |
| Num. H-bond donors | 0 |
| Rotatable bonds | 5 |
| Topological polar surface area | 61.58 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | Xie Y, Chen Y, Guo Y, Huang Y, Zhu B. Allicin and Glycyrrhizic acid display antiviral activity against latent and lytic Kaposi sarcoma-associated herpesvirus. Infectious Microbes & Diseases. 2020 Mar 1;2(1):30-4. Aviello G, Abenavoli L, Borrelli F, Capasso R, Izzo AA, Lembo F, Romano B, Capasso F. Garlic: empiricism or science?. Natural Product Communications. 2009 Dec;4(12):1934578X0900401231. |
