Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD048 |
| Compound Name | Thymol |
| Phytochemical category | Phenolic monoterpenoid |
| PubChem Id | 6989 |
| IUPAC Name | 5-methyl-2-propan-2-ylphenol |
| Molecular Formula | C10H14O |
| Canonical SMILES Notation | CC1=CC(=C(C=C1)C(C)C)O |
| Binomial Name | Cinnamonium verum |
| Vernacular Names | Pattai//Dalchini/Cinnamon |
| Plant Part | Tree bark |
| Family | ?Lauraceae |
| Description | Herpes simplex virus type 1, Human rhinoviruses and Influenza viruses |
| Mechanism of action | ?It inhibits viral host cell fusion via depletion of viral cholesterol from the HIV-1 envelope membranes, thus blocking the entry of the virus into the host system |
| Molecular weight | 150.22 g/mol |
| XLOGP3 | 3.49 |
| Num. H-bond acceptors | 1 |
| Num. H-bond donors | 1 |
| Rotatable bonds | 1 |
| Topological polar surface area | 20.23 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | Sharifi-Rad J, Salehi B, Schnitzler P, Ayatollahi SA, Kobarfard F, Fathi M, Eisazadeh M, Sharifi-Rad M. Susceptibility of herpes simplex virus type 1 to monoterpenes thymol, carvacrol, p-cymene and essential oils of Sinapis arvensis L., Lallemantia royleana Benth. and Pulicaria vulgaris Gaertn. Cellular and Molecular Biology. 2017 Aug 30;63(8):42-7. |
