Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD033 |
| Compound Name | Menthol |
| Phytochemical category | Phenolic monoterpenoid |
| PubChem Id | 1254 |
| IUPAC Name | 5-methyl-2-propan-2-ylcyclohexan-1-ol |
| Molecular Formula | C10H20O |
| Canonical SMILES Notation | CC1CCC(C(C1)O)C(C)C |
| Binomial Name | Mentha piperita |
| Vernacular Names | Pudina/Peppermint |
| Plant Part | Leaf |
| Family | Lamiaceae |
| Description | Influenza A, Coxsackievirus B, Newcastle disease, Herpes simplex, Vaccinia, Semliki Forest and West Nile viruses |
| Mechanism of action | It stimulates TRPM8 blocks TRPV1-mediated mitochondrial fragmentation following viral exposure and attenuates infection. |
| Molecular weight | 156.27 g/mol |
| XLOGP3 | 3.4 |
| Num. H-bond acceptors | 1 |
| Num. H-bond donors | 1 |
| Rotatable bonds | 1 |
| Topological polar surface area | 20.23 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | Taylor DJ, Hamid SM, Andres AM, Saadaeijahromi H, Piplani H, Germano JF, Song Y, Sawaged S, Feuer R, Pandol SJ, Sin J. Antiviral effects of menthol on Coxsackievirus B. Viruses. 2020 Apr;12(4):373. Singh R, Shushni MA, Belkheir A. Antibacterial and antioxidant activities of Mentha piperita L. Arabian Journal of Chemistry. 2015 May 1;8(3):322-8. |
