Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD028 |
| Compound Name | Glycyrrhizic Acid |
| Phytochemical category | Triterpenoid |
| PubChem Id | 14982 |
| IUPAC Name | (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid |
| Molecular Formula | C42H62O16 |
| Canonical SMILES Notation | CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C |
| Binomial Name | Glycyrrhiza glabra |
| Vernacular Names | Licorice/Adhimadhuram |
| Plant Part | Rhizome |
| Family | Fabaceae |
| Description | SARS, Influenza, Respiratory syndrome, Varicella, hepatitis B, Herpes simplex 1, and HIV. |
| Mechanism of action | It inhibits viral replication and immune regulation. |
| Molecular weight | 822.93 g/mol |
| XLOGP3 | 2.8 |
| Num. H-bond acceptors | 16 |
| Num. H-bond donors | 8 |
| Rotatable bonds | 7 |
| Topological polar surface area | 267.04 Ų |
| Bioavailability Score | 0.11 |
| Druglikeness | No |
| Lipinski | 3 violations |
| References | Fiore C, Eisenhut M, Krausse R, Ragazzi E, Pellati D, Armanini D, Bielenberg J. Antiviral effects of Glycyrrhiza species. Phytother Res. 2008;22:141?148. Sun ZG, Zhao TT, Lu N, Yang YA, Zhu HL. Research progress of glycyrrhizic acid on antiviral activity. Mini reviews in medicinal chemistry. 2019 Jun 1;19(10):826-32. |
