Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD015 |
| Compound Name | Diallyl trisulfide |
| Phytochemical category | Trisulfide |
| PubChem Id | 16315 |
| IUPAC Name | 3-(prop-2-enyltrisulfanyl)prop-1-ene |
| Molecular Formula | C6H10S3 |
| Canonical SMILES Notation | C=CCSSSCC=C |
| Binomial Name | Allium sativum |
| Vernacular Names | Vellaipoondu/Lasan/Vellulli/Garlic |
| Plant Part | Shoot/Bulb |
| Family | Alliaceae |
| Description | Influenza B, Herpes simplex virus type 1 and type 2, Human immunodeficiency virus, and SARS-CoV-2. |
| Mechanism of action | It inhibits the replication in earlier period of viral cycle before viral DNA synthesis; reduces the viral load. |
| Molecular weight | 178.34 g/mol |
| XLOGP3 | 2.64 |
| Num. H-bond acceptors | 0 |
| Num. H-bond donors | 0 |
| Rotatable bonds | 6 |
| Topological polar surface area | 75.90 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | Shoji S, Furuishi K, Yanase R, Miyazaka T, Kino M. Allyl compounds selectively killed human immunodeficiency virus (type 1)-infected cells. Biochemical and biophysical research communications. 1993 Jul 30;194(2):610-21. Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC. Antiviral properties of garlic: in vitro effects on influenza B, herpes simplex and coxsackie viruses. Planta medica. 1985 Oct;51(05):460-1. |
