Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD005 |
| Compound Name | Baicalein |
| Phytochemical category | Flavonoid |
| PubChem Id | 5281605 |
| IUPAC Name | 5,6,7-trihydroxy-2-phenylchromen-4-one |
| Molecular Formula | C15H10O5 |
| Canonical SMILES Notation | C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O |
| Binomial Name | Oroxylum indicum |
| Vernacular Names | Vanga Maram/bhut-vriksha/Indian trumpet flower |
| Plant Part | Seed |
| Family | Bignoniaceae |
| Description | Dengue, Influenza viruses, Enterovirus 71, and Japanese Encephalitis Virus. |
| Mechanism of action | It inhibits the viral adsorption and replication by targeting the activity of neuraminidase and non-structural viral proteins. |
| Molecular weight | 270.24 g/mol |
| XLOGP3 | 3.16 |
| Num. H-bond acceptors | 5 |
| Num. H-bond donors | 3 |
| Rotatable bonds | 1 |
| Topological polar surface area | 90.90 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | Zandi K, Teoh BT, Sam SS, Wong PF, Mustafa MR, AbuBakar S. Novel antiviral activity of baicalein against dengue virus. BMC complementary and alternative medicine. 2012 Dec;12(1):1-9. Ding Y, Dou J, Teng Z, Yu J, Wang T, Lu N, Wang H, Zhou C. Antiviral activity of baicalin against influenza A (H1N1/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase. Archives of virology. 2014 Dec 1;159(12):3269-78. |
