Indian Plant Antiviral Compound Database (IMPAC)
| Indian Plant Antiviral Compound | Description |
|---|---|
| InAVPCDB Accession Number | AVD003 |
| Compound Name | Andrographolide |
| Phytochemical category | Diterpenoid |
| PubChem Id | 5318517 |
| IUPAC Name | (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one |
| Molecular Formula | C20H30O5 |
| Canonical SMILES Notation | CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O |
| Binomial Name | Andrographis paniculata |
| Vernacular Names | Nilavembu/Nela Vemu/Kalmegh/Green Chiretta |
| Plant Part | Stem and Leaf |
| Family | Acanthaceae |
| Description | Influenza, Hepatitis, Dengue, Simian Retro Virus, Chikungunya, and SARS-CoV-2. |
| Mechanism of action | It restrain viral replication by inhibiting viral proteases , and viral adsorption onto red blood cells in the host. |
| Molecular weight | 350.45 g/mol |
| XLOGP3 | 2.16 |
| Num. H-bond acceptors | 5 |
| Num. H-bond donors | 3 |
| Rotatable bonds | 3 |
| Topological polar surface area | 86.99 Ų |
| Bioavailability Score | 0.55 |
| Druglikeness | Yes |
| Lipinski | 0 violation |
| References | Sa-Ngiamsuntorn K, Suksatu A, Pewkliang Y, Thongsri P, Kanjanasirirat P, Manopwisedjaroen S, Charoensutthivarakul S, Wongtrakoongate P, Pitiporn S, Chaopreecha J, Kongsomros S. Anti-SARS-CoV-2 activity of Andrographis paniculata extract and its major component Andrographolide in human lung epithelial cells and cytotoxicity evaluation in major organ cell representatives. Journal of Natural products. 2021 Apr 12;84(4):1261-70. Gupta S, Mishra KP, Ganju L. Broad-spectrum antiviral properties of andrographolide. Archives of virology. 2017 Mar;162(3):611-23. |
